Raul Andino

1 week ago | cell.com | Raul Andino |Daniel Darling

Get full text accessLog in, subscribe or purchase for full access. References1. Genoyer, E. ∙ Wilson, J. ∙ Ames, J.M. ... Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virusMol. Cell. 2025; 85:1147-1161.e92. Chow, K.T. ∙ Gale, Jr., M. ∙ Loo, Y.-M. RIG-I and Other RNA Sensors in Antiviral ImmunityAnnu. Rev. Immunol. 2018; 36:667-6943. Yoneyama, M. ∙ Kikuchi, M. ∙ Natsukawa, T. ...

Aug 28, 2024 | nature.com | Michael J Peluso |Michelle Davidson |Sarah Goldberg |Jessica Chen |Badri Viswanathan |Kevin C. Donohue | +8 more

AbstractTo understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Participants self-collected up to 21 nasal specimens within the first 28 days post-symptom onset; interviewer-administered questionnaires and blood samples were collected at enrollment, days 9, 14, 21, 28, and month 4 and 8 post-symptom onset.

May 13, 2024 | nature.com | Raul Andino

AbstractHuntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine (polyQ) tract. Although mutant HTT (mHTT) protein is known to aggregate, the links between aggregation and neurotoxicity remain unclear.