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Nov 18, 2024 | 
nature.com | Alton Barbehenn |Vivian Pae |Sannidhi Sarvadhavabhatla |Michael J Peluso |Jeffrey Martin |Frederick M. Hecht | +7 more
AbstractDespite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells.
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Nov 13, 2024 | 
science.org | Sharon Saydah |Michael J Peluso |Julio César Silva |Júlio Silva |Alexandra Schafer
AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because of the emergence of SARS-CoV-2 variants that can cause severe acute coronavirus disease 2019 (COVID-19) or enhance Long Covid disease phenotypes.
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Nov 13, 2024 | 
science.org | Sharon Saydah |Michael J Peluso |Julio César Silva |Júlio Silva |Rebecca Hamlin
Editor’s summarySex differences have been reported for both acute coronavirus disease 2019 (COVID-19) and Long Covid (LC), with males typically having more severe acute disease and females being more likely to develop LC. Here, Hamlin et al. performed multiomics on peripheral blood samples from a prospective cohort of individuals to understand why. The authors identified immune pathways during acute infection that were associated with later development of LC.
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Nov 13, 2024 | 
science.org | Sharon Saydah |Michael J Peluso |Julio César Silva |Júlio Silva |Andrea Cox
AbstractLong Covid is defined by a wide range of symptoms that persist after the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported symptoms include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other symptoms reported.
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Oct 9, 2024 | 
sciencedirect.com | M. Ahmed |Michael J Peluso |Jeffrey Martin |M.D.H. Hawlader
Persistent symptoms following the acute phase of COVID-19, termed postacute sequelae of COVID-19 (PASC), or long COVID-19, is a multisystemic condition affecting an estimated 10% of individuals following SARS-CoV-2 infection [1]. PASC is associated with a wide array of symptoms representing most organ systems, encompasses a heterogeneous set of pathophysiological processes, and can substantially affect the quality of life [[2], [3], [4]].
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Aug 28, 2024 | 
nature.com | Michael J Peluso |Michelle Davidson |Sarah Goldberg |Jessica Chen |Badri Viswanathan |Kevin C. Donohue | +8 more
AbstractTo understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Participants self-collected up to 21 nasal specimens within the first 28 days post-symptom onset; interviewer-administered questionnaires and blood samples were collected at enrollment, days 9, 14, 21, 28, and month 4 and 8 post-symptom onset.
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Oct 24, 2023 | 
onlinelibrary.wiley.com | Matthew S. Durstenfeld |Michael J Peluso |Feng Lin |Noah D. Peyser
1 INTRODUCTION Symptoms after SARS-CoV-2 may persist as Long COVID, a type of postacute sequalae of SARS-CoV-2 infection (PASC) defined as unexplained symptoms attributed to COVID-19.1 Vaccination reduces but does not eliminate risk of Long COVID.2 Higher acute viral load or prolonged shedding may be associated with increased risk.3, 4 Recent studies suggest viral persistence in a subset of individuals with PASC, including prolonged gastrointestinal shedding, ongoing Spike and Nucleocapsid...
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Jul 19, 2023 | 
nature.com | Danillo G. Augusto |Lawton D. Murdolo |Noah D. Peyser |Victoria W. Murray |Cassandra Yun |Colin T. Maguire | +10 more
AbstractStudies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic1,2,3,4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance.
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Jul 13, 2023 | 
nature.com | Daniel Reeves |Thiago Oliveira |Michael J Peluso |Joshua T Schiffer |Steven Deeks
Human participantsThis study was approved by the institutional review board of the NIH National Institute of Allergy and Infectious Diseases and registered on ClinicalTrials.gov: NCT00039689. All study participants provided written informed consent, and leukapheresis products were collected in accordance with the protocol. All study participants were of male sex based on self-reporting. 5 participants were White, 3 Black and 2 Unknown/Hispanic-Latino.
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Apr 17, 2023 | 
forbes.com | Michael J Peluso
Healthcare centers are still struggling to hire and retain staff. An estimated 1.5 million healthcare jobs were lost at the onset of the pandemic, and managers are trying to get staffing numbers back to levels seen in 2019. The front desk is the first glimpse patients have into your practice, so making the process as easy and painless as possible is crucial.
