Raymond T. Suhandynata

Feb 29, 2024 | biorxiv.org | Henry Ng |Armin N. Adly |Raymond T. Suhandynata |Devon H. Whelpley

AbstractCell cycle progression is governed by complexes of the cyclin-dependent kinases (CDKs) and their regulatory subunits cyclin and Cks1. CDKs phosphorylate hundreds of substrates, often at multiple sites. Multisite phosphorylation depends on Cks1, which binds initial priming phosphorylation sites to promote secondary phosphorylation at other sites. Here, we describe a similar role for a recently discovered phosphate-binding pocket (PP) on B-type cyclins.