Rebecca Rodell

2 months ago | cell.com | Ning Tsao |Patrick Lombardi |Ajin Park |Jennifer Olabode |Rebecca Rodell |Hua Sun | +6 more

KeywordsRNAR-loopsYTH domainbase damagealkylationGet full text accessLog in, subscribe or purchase for full access. References1. Fu, D. ∙ Calvo, J.A. ∙ Samson, L.D.Balancing repair and tolerance of DNA damage caused by alkylating agentsNat. Rev. Cancer. 2012; 12:104-1202. Soll, J.M. ∙ Sobol, R.W. ∙ Mosammaparast, N. Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic OpportunitiesTrends Biochem. Sci. 2017; 42:206-2183.

Dec 14, 2023 | cell.com | Rebecca Rodell |Nicolas Robalin |Nicole Martinez |Chan Zuckerberg Biohub

Highlights mRNA modifications impact the mRNA life cycle. Pseudouridine (Ψ) is the most prevalent uridine modification in mRNA. There have been recent developments in technologies to quantify and to study the functions of Ψ, particularly in mRNA. Ψ residues in mRNA have functions in splicing, translation, and stability. The presence and regulation of uridine modifications in mRNA urge future studies into their functions.