Chan Zuckerberg Biohub

Jan 9, 2025 | phys.org | Chan Zuckerberg Biohub

Like workers at a factory or office, proteins in a cell must be in the right department to do their jobs. But scientists have yet to fully map the cell's organization, much less determine how these cellular "employees" may be reassigned in a time of crisis or change. A hostile takeover by a virus, for example, can send a cell's proteins to new stations, from which they may either serve the pathogen's aims or help the cell as it attempts to resist the infection.

Nov 25, 2024 | genomebiology.biomedcentral.com | Chan Zuckerberg Biohub

ReferencesNoonan JP, McCallion AS. Genomics of Long-range regulatory elements. Annu Rev Genomics Hum Genet. 2010;11:1–23. Article  CAS  PubMed  Google Scholar  Sabarís G, Laiker I, Preger-Ben Noon E, Frankel N. Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity. Trends Genet. 2019;35:423–33. The GTEx Consortium. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science. 2020;369:1318–30. Perez RK, et al.

Nov 21, 2024 | genome.cshlp.org | Samuel Kim |Georgi K. Marinov |William J. Greenleaf |Chan Zuckerberg Biohub

2 1 Stanford University; 2 Stanford University, Chan Zuckerberg Biohub ↵* Corresponding author; email: marinovg{at}stanford.edu Received May 24, 2024. Accepted November 19, 2024. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml).

Nov 4, 2024 | cell.com | Peter J. Turnbaugh |Chan Zuckerberg Biohub

Keywordsautoimmune diseasegut microbiomeketogenic dietketogenesisimmune activationneuroinflammationmultiple sclerosislactobacillustrytophan metabolismnutritionResearch topic(s)CP: MicrobiologyCP: ImmunologyIntroductionDiet has broad impacts on autoimmune disease, including multiple sclerosis (MS), inflammatory bowel disease, and rheumatoid arthritis,11. Sanchez, J.M.S. ∙ DePaula-Silva, A.B. ∙ Libbey, J.E. ... Role of diet in regulating the gut microbiota and multiple sclerosisClin. Immunol.

Oct 28, 2024 | jamanetwork.com | Alison Rose Ohringer |Chan Zuckerberg Biohub

Guideline-Directed Medical Therapy Intolerance in Heart Failure An 89-year-old woman with severe peripheral arterial disease and chronic left lower extremity limb ischemia, heart failure with reduced ejection fraction (HFrEF) of 35% to 40%, and paroxysmal atrial flutter presented to the emergency department for lethargy, weakness, and left foot pain for 1 week. Eighteen months prior, the patient was diagnosed with HFrEF.