Refaah Mousa Al-Jassas

May 30, 2023 | onlinelibrary.wiley.com | Mohammad Shahidul Islam |Abdullah Mohammed Al-Majid |Mohamed S. Nafie |Refaah Mousa Al-Jassas

A series of 16 novel spirooxindole analogs 8a–p were designed and constructed via cost-effective single-step multicomponent [3+2] cycloaddition reaction of azomethine ylide (AY) generated in situ from substituted isatin (6a–d) with suitable amino acids (7a–c) and ethylene-engrafted pyrazole derivatives (5a,b). The potency of all compounds was assayed against a human breast cancer cell line (MCF-7) and a human liver cell line (HepG2).