Reinhard P. Gruber

Dec 23, 2024 | mdpi.com | Reinhard P. Gruber

1. IntroductionHyaluronic acid (HAc) is a non-sulfated glycosaminoglycan composed of repeating β(1–4)-glucuronic acid and β(1ߝ3)-N-acetyl glucosamine heterodimers. HAc is a major component of the extracellular matrix predominantly produced by cells of the mesenchymal lineage, represented by synoviocytes and chondrocytes in a joint, with its main function in the synovial fluid integrating viscoelasticity and hygroscopic properties, and bolstering cartilage to become a shock absorber [,].

Dec 13, 2024 | mdpi.com | Reinhard P. Gruber

1. IntroductionInflammation, when transient, is an evolutionally conserved process that is an essential requirement of innate immunity and signals the need for repair in wound healing [1] and bone regeneration [2]. On the other hand, chronic inflammation is a pathological process where resolution is impaired, and catabolic events accumulate and cause tissue destruction, exemplified by rheumatoid arthritis, Crohn’s disease, and periodontitis, to name a few [3,4,5].

Nov 30, 2023 | onlinelibrary.wiley.com | Richard Miron |Reinhard P. Gruber |Nima Farshidfar |Anton Sculean

1 INTRODUCTION The use of platelet concentrates has gained tremendous popularity in the fields of regenerative medicine and dentistry owing to their ability to speed healing through improving neovascularization.1 Platelet-rich plasma (PRP) is derived from peripheral blood following centrifugation with anticoagulants. Over the years, a second-generation platelet concentrate was developed with the main aim of anticoagulant removal.