Richard Miller

Nov 26, 2024 | nature.com | Richard Miller

AbstractRestricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or adult mice. However, their effects when initiated in aged animals are unknown. Here we investigate the consequences of consuming a diet with 67% reduction of all amino acids (low AA) or of isoleucine alone (low Ile), in male and female C57BL/6J.Nia mice starting at 20 months of age.

Jul 29, 2024 | nature.com | Richard Miller

ReferencesSagan, C. Pale Blue Dot: A Vision of the Human Future in Space (Random House, 1994). Google Scholar  Widjaja, A. A. et al. Nature 632, 157–165 (2024). Article  Google Scholar  Aguiar-Oliveira, M. H. & Bartke, A. Endocr. Rev. 40, 575–601 (2019). Article  PubMed  Google Scholar  Orentreich, N., Matias, J. R., DeFelice, A. & Zimmerman, J. A. J. Nutr. 123, 269–274 (1993). PubMed  Google Scholar  Weindruch, R. & Sohal, R. S. N. Engl. J. Med. 337, 986–994 (1997).

Aug 12, 2023 | mdpi.com | Jonathan P Tyrer |Ravi Shah |Richard Miller |Chrysothemis Paraskevopoulou

5. Numerical ResultsThis section presents and evaluates the results with some meaningful reasoning towards the models’ responses to the excavation based on the numerical findings while comparing the 2D and 3D analyses. 5.1. PLAXIS2D and RS2 AnalysisThe PLAXIS2D simulation revealed full settlement profiles (Figure 8a) for each of the constitutive models after the installation of the final lining, as well as a soil element test for calibration.