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Jan 24, 2025 | 
knowridge.com | Mona Bafadhel |Richard Russell
Every 30 seconds, someone in the world will experience a flare-up of their asthma or chronic obstructive pulmonary disease (COPD) symptoms. For decades, the standard treatment for these potentially life-threatening episodes has remained unchanged – treatment with steroids, such as prednisolone. Unfortunately, these drugs don’t work for everyone and they have significant levels of serious side-effects.
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Nov 29, 2024 | 
msn.com | Mona Bafadhel |Richard Russell |Sanjay Ramakrishnan
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Nov 28, 2024 | 
kcl.ac.uk | Mona Bafadhel |Richard Russell
The findings, published today in The Lancet Respiratory Medicine, could be “game-changing” for millions of people with asthma and COPD around the world, scientists say. Asthma attacks and COPD flare-ups (also called exacerbations) can be deadly. Every day in the UK four people with asthma and 85 people with COPD will tragically die. Both conditions are also very common, in the UK someone has an asthma attack every 10 seconds. Asthma and COPD costs the NHS £5.9B a year.
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Apr 18, 2024 | 
kcl.ac.uk | Mona Bafadhel |Richard Russell
The collaborative research, led from the University of Oxford, has developed a new tool that more accurately predicts risk of cardiovascular diseasesCollaborative research, led from the University of Oxford and published today in Nature Medicine, has developed a new tool called QR4 that more accurately predicts an individual's 10-year risk of cardiovascular diseases, like heart disease and stroke, particularly identifying high-risk patients that current prediction tools miss.
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Apr 4, 2024 | 
erj.ersjournals.com | Gauvreau GM |O'Byrne PM |Boulet LP |Richard Russell
IntroductionAsthma is a heterogeneous disease involving diverse underlying pathobiological mechanisms with different clinical manifestations, typically characterised by excessive inflammatory and bronchoconstrictor responses to the environment. Asthma occurs as a result of the interaction between environmental and host factors over time.
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Feb 29, 2024 | 
bmjopen.bmj.com | Rachel Cooney |Kevin Barrett |Richard Russell
MethodsThe study protocol was specified a priori and registered with ClinicalTrials.gov (Study identifier: NCT05206734). Post hoc protocol changes are described in online supplemental appendix 1. This study used routinely collected primary care data. There was no patient or public involvement in the development of the study design.
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Nov 30, 2023 | 
bjgp.org | Gillian Doe |Stephanie Taylor |Marko Topalovic |Richard Russell |Stephanie Taylor |Richard Russell | +11 more
AbstractBackground Spirometry services to diagnose and monitor lung disease in primary care were identified as a priority in the NHS Long Term Plan, and are restarting post-COVID-19 pandemic in England; however, evidence regarding best practice is limited. Aim To explore perspectives on spirometry provision in primary care, and the potential for artificial intelligence (AI) decision support software to aid quality and interpretation.
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Nov 27, 2023 | 
thorax.bmj.com | Joseph Emil Amegadzie |Zhiwei Gao |Jennifer K Quint |Richard Russell
DiscussionWe used a representative sample of UK English primary care patients with COPD to evaluate the incidence and 10 year risk of CVD at the time of COPD diagnosis and determined to what extent QRISK3 can accurately predict CVD risk in people living with COPD. We showed that for both men and women, the incidence of CVD in people with COPD is substantially higher than in the general population, particularly among younger people with COPD.
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Nov 6, 2023 | 
racingpost.com | Richard Russell
Three horses to include in a multiple on Tuesday . . . The Ice Phoenix (12.07 Lingfield)Charlie Hills’s two-year-old was too green to do himself justice when introduced in a traditionally warm maiden at Newmarket’s July festival, but showed what he was capable of when a decent second on the all-weather next time. Returned to turf for his third start, he finished a fine third at Ascot in a race that’s worked out well, with the winner, second and fifth all going in next time.
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Sep 25, 2023 | 
racingpost.com | Richard Russell
Three horses to include in a multiple on Tuesday . . . Bibendum (2.25 Lingfield)Kicked his career off by chasing home Seven Questions and Red Zone Hero over 6f at Yarmouth - form which just gets better with every passing week - and did well on his second start, filling the runner-up spot at Wolverhampton from a wide draw. Can be excused a no-show in a big sales race at the Ebor meeting last time and now drops a furlong for his handicap debut.
