Rick Jansen

Jun 6, 2024 | nature.com | Rick Jansen |Yuri Milaneschi |Boadie W Dunlop |A. John Rush

AbstractMajor Depressive Disorder (MDD) is a common, frequently chronic condition characterized by substantial molecular alterations and pathway dysregulations. Single metabolite and targeted metabolomics platforms have revealed several metabolic alterations in depression, including energy metabolism, neurotransmission, and lipid metabolism. More comprehensive coverage of the metabolome is needed to further specify metabolic dysregulations in depression and reveal previously untargeted mechanisms.