Yuri Milaneschi

Jun 6, 2024 | nature.com | Rick Jansen |Yuri Milaneschi |Boadie W Dunlop |A. John Rush

AbstractMajor Depressive Disorder (MDD) is a common, frequently chronic condition characterized by substantial molecular alterations and pathway dysregulations. Single metabolite and targeted metabolomics platforms have revealed several metabolic alterations in depression, including energy metabolism, neurotransmission, and lipid metabolism. More comprehensive coverage of the metabolome is needed to further specify metabolic dysregulations in depression and reveal previously untargeted mechanisms.

Mar 18, 2024 | cambridge.org | Yuri Milaneschi |Jouke-Jan Hottenga |Mariska Bot |Floris Huider

Major depressive disorder (MDD) is a mental health condition characterized by decreased mood and anhedonia that severely impacts quality of life. It affects up to 20% of the population across the lifetime and is a leading contributor to disability worldwide (Kessler & Bromet, Reference Kessler and Bromet2013; Marx et al., Reference Marx, Penninx, Solmi, Furukawa, Firth, Carvalho and Berk2023; World Health Organization [WHO], 2017).

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Nov 20, 2023 | cambridge.org | Yuri Milaneschi |Femke Lamers |Christiaan H Vinkers |Camille Souama

More than a third of the population reports a history of childhood trauma (CT), including emotional abuse and neglect, physical abuse and neglect, as well as sexual abuse (Redican, Murphy, McBride, Bunting, & Shevlin, Reference Redican, Murphy, McBride, Bunting and Shevlin2022; Witt, Brown, Plener, Brähler, & Fegert, Reference Witt, Brown, Plener, Brähler and Fegert2017).

Apr 10, 2023 | biologicalpsychiatryjournal.com | Yara J. Toenders |Xueyi Shen |Yuri Milaneschi |Laura Han

Two independent mega-analyses across a total of 32 cohorts and >3,400 patients and >2,800 controls worldwide revealed that persons with major depressive disorder (MDD) show older appearing brains compared to non-depressed peers. However, the biological mechanisms underlying the age-related structural brain alterations remain unknown. Here, we examined whether variations in the “brain age gap” were linked to variations in polygenic risk for several depression-related traits.