Rinako Nakagawa

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Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation - Nature Communications

Dec 2, 2024 | nature.com | Rinako Nakagawa |Miriam Llorian |Neil L. Kelleher |Robert Klose |Martin R. Turner

AbstractTo increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously proliferate by utilizing energy provided by oxidative phosphorylation (OXPHOS).

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