Roarke A. Kamber

1 month ago | biorxiv.org | Stefan M. Lundgren |Roarke A. Kamber |Michael Bassik |Emel Akdoğan

AbstractLevels of receptors on the cell surface control the sensitivity of immune cells, which is central to achieving effective responses while avoiding inflammatory diseases. The chemoattractant receptor FPR1 activates strong chemotactic and cytotoxic responses in neutrophils. While its precise regulation is critical for appropriate responses, the mechanisms controlling its cell surface levels remain unclear. Here, we investigated the roles of both classic and unknown regulators.