Stefan M. Lundgren

1 month ago | biorxiv.org | Stefan M. Lundgren |Roarke A. Kamber |Michael Bassik |Emel Akdoğan

AbstractLevels of receptors on the cell surface control the sensitivity of immune cells, which is central to achieving effective responses while avoiding inflammatory diseases. The chemoattractant receptor FPR1 activates strong chemotactic and cytotoxic responses in neutrophils. While its precise regulation is critical for appropriate responses, the mechanisms controlling its cell surface levels remain unclear. Here, we investigated the roles of both classic and unknown regulators.

Oct 3, 2023 | science.org | Stefan M. Lundgren |Katharina Aigner-Radakovics |Amy Baek |Briana L. Rocha-Gregg

Published In Science SignalingVolume 16 | Issue 805October 2023Article versionsSubmission historyReceived: 27 May 2022Accepted: 23 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank the Flow Cytometry Shared Resource at UC Davis and directors B. McLaughlin and J. Van Dyke for support and guidance. We also thank J. Albeck, M. Burns, M. Huising, and the Collins laboratory members G. Bell, D. Sernas, K. Badu-Nkansah, and E.

Oct 3, 2023 | science.org | Stefan M. Lundgren |Katharina Aigner-Radakovics |Amy Baek

Published In Science SignalingVolume 16 | Issue 805October 2023Article versionsSubmission historyReceived: 12 December 2022Accepted: 30 August 2023PermissionsRequest permissions for this article. AcknowledgmentsWe are grateful to H.J. Gabius for providing biotinylated Galectin-3. We wish to thank M. Kundi and H. Zipko for statistical consultancy and C. Wenhardt for technical assistance. BioRender.com was used to generate schemes in Figs. 1, 2, 4, and 7.

Oct 3, 2023 | science.org | Stefan M. Lundgren |Amy Baek |Katharina Aigner-Radakovics

Editors' ChoiceIMMUNOLOGYT cells are essential for mounting immune responses against infections and cancers but can become exhausted and lose effector function after chronic antigen exposure. Given that T cells express adrenergic receptors and that T cell responses can be affected, at least indirectly, by the sympathetic nervous system, Globig et al. investigated whether adrenergic stress signaling in mice regulates T cells directly.

Oct 3, 2023 | sciencemag.org | Stefan M. Lundgren |Katharina Aigner-Radakovics |Amy Baek

Editors' ChoiceIMMUNOLOGYT cells are essential for mounting immune responses against infections and cancers but can become exhausted and lose effector function after chronic antigen exposure. Given that T cells express adrenergic receptors and that T cell responses can be affected, at least indirectly, by the sympathetic nervous system, Globig et al. investigated whether adrenergic stress signaling in mice regulates T cells directly.