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1 week ago | 
healio.com | Rob Volansky
Health care workers seeking deep meditations and hard-won wisdom on clinical reasoning, mentorship, empathy and learning from mistakes now have a text offering a comprehensive look at the profession. The book, titled Masterclass in Medicine: Lessons from the Experts, features patient stories and personal reflections from a cross section of health care professionals.
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2 weeks ago | 
healio.com | Rob Volansky
Increasing wildfire incidence, along with greater overall air pollution, may be contributing to risks for rheumatoid arthritis and RA-associated interstitial lung disease, according to findings published in Arthritis & Rheumatology. “All these increasing wildfires are bad news for everyone, especially people with conditions that are known to be exacerbated by pollution,” Vanessa L. Kronzer, MD, a rheumatologist at the Mayo Clinic, in Rochester, Minnesota, told Healio.
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3 weeks ago | 
healio.com | Rob Volansky
The FDA has granted orphan drug designation to rilzabrutinib for IgG4-related disease and warm autoimmune hemolytic anemia, according to a press release from the manufacturer. There are currently no FDA-approved therapies for either of these conditions.
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3 weeks ago | 
healio.com | Rob Volansky |Shenaz Bagha
A risk prediction score that uses machine learning and a patient’s genetic information may identify autoimmune conditions up to 1,000% more accurately than current models, according to findings published in Nature Communications.
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3 weeks ago | 
healio.com | Rob Volansky |Shenaz Bagha
Read more Learning from 2 decades of off-label rituximab use in systemic lupus erythematosus may point the way toward developing “new and improved” B-cell depleting agents for patients with the disease, according to researchers.
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1 month ago | 
healio.com | Rob Volansky |Shenaz Bagha
Rheumatologists and cardiologists have long co-managed patients out of necessity and without much formal collaboration or guidance. However, in recent years, cardio-rheumatology clinics have begun to proliferate, offering more evidence-based algorithms for physicians who treat this crossover patient population.
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1 month ago | 
healio.com | Rob Volansky |Shenaz Bagha |Leonard Calabrese
Last November, results from the MITIGATE trial made headlines at ACR Convergence 2024 with positive phase 3 trial data for inebilizumab, an IgG1 monoclonal antibody targeting CD19, in patients with IgG4-related disease. That trial, the first randomized, double-blind, placebo-controlled study ever conducted in IgG4-RD, confirmed “beyond doubt” that B-cell depletion is an effective treatment strategy for the disease, John H.
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1 month ago | 
healio.com | Rob Volansky |Shenaz Bagha
Although chimeric antigen receptor T-cell therapy has delivered previously unthinkable remission outcomes to patients with lupus and other rheumatic diseases, the cells currently in use remain “old fashioned,” according to a speaker. During a roundtable discussion at the Cleveland Clinic Basic and Clinical Immunology for the Busy Clinician symposium, Maximilian F.
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1 month ago | 
healio.com | Rob Volansky |Shenaz Bagha |Robert Levin
The “big three” pharmacy benefit managers have imposed markups ranging from 100% to more than 7,000% on generic specialty drugs dispensed at their affiliated pharmacies, according to a Federal Trade Commission report released this year. The markups — at CVS Caremark, Express Scripts, and OptumRx — were seen not only in medications to treat cancer and HIV, but also in the rheumatology space. “The FTC really let them have it,” Robert W.
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1 month ago | 
healio.com | Rob Volansky |Shenaz Bagha
Chimeric antigen receptor T-cell therapy improves not only lupus disease activity but also other related conditions that impact quality of life, according to a speaker at the Basic and Clinical Immunology for the Busy Clinician symposium. According toEmily Littlejohn, DO, MPH, of the department of rheumatologic and immunologic disease at the Cleveland Clinic, which hosted the symposium, these include fatigue and Jaccoud’s arthropathy.
