Robert A. Nicholls

Oct 30, 2024 | mdpi.com | Harry Morgan |Robert A. Nicholls |Anna Warren |Simon Ward

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Oct 17, 2024 | biorxiv.org | Robert A. Nicholls |Harry Morgan |Anna Warren |Simon Ward

AbstractDNA gyrase is a type IIA topoisomerase that can create temporary double-stranded DNA breaks to regulate DNA topology and an archetypical target of antibiotics. The widely used quinolone class of drugs use a water-metal ion bridge in interacting with the GyrA subunit of DNA gyrase. Zoliflodacin sits in the same pocket as quinolones but interacts with the GyrB subunit and also stabilizes lethal double-stranded DNA-breaks.

Feb 23, 2024 | medium.com | Robert A. Nicholls

Many will have heard the phrase “” (from PEP8). Recently, I have happily noticed my team referring to “hobgoblins” in our code base. It occurred to me that to identify a hobgoblin, or “a foolish consistency”, is to identify a situation where it makes sense to break with convention. In order to break the rules you have to know them extremely well, hence my happiness. I have always emphasised to my teams the importance of knowing these rules back to front.

Jan 7, 2024 | elperiodico.com | Joan Lluís Ferrer |Robert A. Nicholls |Science Advances

Recreación del animal ahora descubierto / Un grupo de científicos ha localizado los restos fósiles de un nuevo grupo de animales depredadores hasta ahora desconocidos y que, básicamente, consistían en grandes gusanos de más de 30 centímetros de largo y provistos de potentes mandíbulas.