Anna Warren

Nov 12, 2024 | nature.com | Sam Lewis |Anna Warren |Mark Warren

AbstractThe increasing availability of ultrabright Light Sources is facilitating the study of smaller crystals at faster timescales but with an increased risk of severe X-ray damage, leading to developments in multi-crystal methods such as serial crystallography (SX).

Oct 30, 2024 | mdpi.com | Harry Morgan |Robert A. Nicholls |Anna Warren |Simon Ward

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Oct 17, 2024 | biorxiv.org | Robert A. Nicholls |Harry Morgan |Anna Warren |Simon Ward

AbstractDNA gyrase is a type IIA topoisomerase that can create temporary double-stranded DNA breaks to regulate DNA topology and an archetypical target of antibiotics. The widely used quinolone class of drugs use a water-metal ion bridge in interacting with the GyrA subunit of DNA gyrase. Zoliflodacin sits in the same pocket as quinolones but interacts with the GyrB subunit and also stabilizes lethal double-stranded DNA-breaks.