Robert C. Rennert

Nov 13, 2024 | medrxiv.org | Nadia A. Atai |Kristine Ravina |Saman Sizdahkhani |Robert C. Rennert

The authors have declared no competing interest. This publication was made possible by National Institutes of Health R03 grant #5R03NS113090-02 (JJR) and the Alfred E. Mann Charities, Inc (JJR). Its contents are solely the responsibility of the authors. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Oct 21, 2024 | onlinelibrary.wiley.com | Mohamad Saoud |Jan Grau |Robert C. Rennert |Thomas Mueller

1 Introduction Anti-cancer drug discovery usually starts with in vitro viability assays using cancer cell line models, which identify cytotoxic chemicals with high anti-proliferative capacity. At that early stage, knowledge regarding the mechanisms by which cell growth is inhibited is limited.

Sep 27, 2024 | pubs.rsc.org | Erika Samolova |Ibrahim Morgan |Robert C. Rennert

Novel Zn(II), Co(II) and Cu(II) diflunisalato complexes with neocuproine and their exceptional antiproliferative activity against cancer cell lines Three novel complexes of deprotonated diflunisal (dif) with neocuproine (neo) were synthesized and characterized by elemental, spectral (UV-Vis, FTIR, fluorescence, mass spectrometry) and single-crystal X-ray diffraction analysis.

Jun 28, 2024 | thejns.org | William T Couldwell |Robert C. Rennert

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May 21, 2024 | chemistry-europe.onlinelibrary.wiley.com | Manuel Ricardo |Dayma Llanes |Robert C. Rennert |Paul Jänicke

Introduction Antibody-drug conjugates (ADCs)1 and peptide-drug conjugates (PDCs)2 are among the most promising chemotherapeutics for cancer treatment, mainly due to the ability of monoclonal antibodies (mAbs) and homing peptides to selectively deliver potent cytotoxic drugs into tumor cells.