Robin Fallegger

Jul 17, 2024 | biorxiv.org | Aurelien Dugourd |Pascal Lafrenz |Diego Mañanes |Robin Fallegger

AbstractUnderstanding complex diseases requires approaches that jointly analyze omic data across multiple biological layers, including signaling, gene regulation, and metabolism. Existing data-driven multi-omic analysis methods, such as multi-omic factor analysis (MOFA), can identify associations between molecular features and phenotypes, but they are not designed to integrate existing mechanistic molecular knowledge, which can provide further actionable insights.

Jun 10, 2024 | nature.com | Yuvarani Masarapu |Egle Cekanaviciute |Jakub O. Westholm |Asa Bjorklund |Åsa K. Björklund |Pau Badia-i-Mompel | +11 more

AbstractImpairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice.