Robin Pearce

Nov 6, 2023 | dmd.aspetjournals.org | Stephani Stancil |Robin Pearce |Vincent S. Staggs |J. Steven Leeder

AbstractScaling factors are necessary for translating in vitro drug biotransformation data to in vivo clearance values in physiologically-based pharmacokinetic modeling and simulation. Values for microsomal protein per gram of liver are available from several sources for use as a scaling factor to estimate hepatic clearance from microsomal drug biotransformation data.

Sep 21, 2023 | dmd.aspetjournals.org | Stephani Stancil |Robin Pearce |Vincent S. Staggs |J. Steven Leeder

AbstractScaling factors are necessary for translating in vitro drug biotransformation data to in vivo clearance values in physiologically-based pharmacokinetic (PBPK) modeling and simulation. Values for microsomal protein per gram of liver (MPPGL) are available from several sources for use as a scaling factor to estimate hepatic clearance from microsomal drug biotransformation data.