Vincent S. Staggs

Sep 16, 2024 | jamanetwork.com | Kansas City |Lauren Davidson |Vincent S. Staggs |Hannah Suffian

Key PointsQuestion  What are the racial and ethnic distributions observed among participants in food allergy immunotherapy trials? Findings  In this systematic review of 26 randomized clinical trials, the predominant racial demographic group represented within food allergy immunotherapy clinical trials was White. In contrast, Black and Hispanic participants were underrepresented despite an increased disease burden in these populations.

May 23, 2024 | dialnet.unirioja.es | Lauren Clark |Peng Shi |Vincent S. Staggs |Jiexiang Hu

Bayesian Hierarchical Factor Analysis for Eficient Estimation Across Race/EthnicityAutores: Jiexiang Hu, Lauren Clark, Peng Shi, Vincent S. Staggs, Christine M. Daley, Byron J GajewskiLocalización: Revista Colombiana de Estadística, ISSN-e 2389-8976, ISSN 0120-1751, Vol. 44, Nº. 2, 2021, págs.

Apr 17, 2024 | ascpt.onlinelibrary.wiley.com | Kathryn E. Kyler |Andrea Gaedigk |Susan M. Abdel-Rahman |Vincent S. Staggs

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? A prior study reported a novel CYP2C haplotype (CYP2C:TG) that was functionally similar to that of the increased function CYP2C19*17 allele. The CYP2C:TG haplotype was described to confer increased activity toward CYP2C19 substrates (e.g., escitalopram) similar to that of CYP2C19*17. WHAT QUESTION DID THIS STUDY ADDRESS?

Nov 6, 2023 | dmd.aspetjournals.org | Stephani Stancil |Robin Pearce |Vincent S. Staggs |J. Steven Leeder

AbstractScaling factors are necessary for translating in vitro drug biotransformation data to in vivo clearance values in physiologically-based pharmacokinetic modeling and simulation. Values for microsomal protein per gram of liver are available from several sources for use as a scaling factor to estimate hepatic clearance from microsomal drug biotransformation data.

Oct 11, 2023 | mdpi.com | Jeremy Stewart |Nathan R Fleishman |Vincent S. Staggs |Mike Thomson

2. Materials and Methods 2.1. Ethical Conduct of Research Review and approval were granted by our institutional research integrity body (Children’s Mercy Institutional Review Board Study #00001539 effective 10 May 2020). Informed consent was waived as it was not applicable as per the IRB determination.