Roger Calderon

Nov 28, 2024 | nature.com | Yang Luo |Xin Wang |Qingyun Liu |Junhao Zhu |Roger Calderon |Sahadevan Raman | +4 more

AbstractInfectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.06, 95%CI: 4.87 − 20.77, P = 7.92 × 10−8) in the FLOT1 gene and a subclavaluee of Mtb Lineage 2.