Articles
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Jan 22, 2025 |
dx.doi.org | Xin Wang |Wei Jia |Rong Zhang |Lin Shi
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Jan 22, 2025 |
pubs.acs.org | Xin Wang |Wei Jia |Rong Zhang |Lin Shi
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Dec 20, 2024 |
nature.com | Xin Wang
AbstractPeripheral T cell lymphoma (PTCL) is characterized by high heterogeneity, strong aggressiveness, and extremely poor prognosis. Ferroptosis, a novel form of programmed cell death, has been involved in tumor development and targeting ferroptosis holds great potential for tumor therapy. Lentiviral transfection was performed to regulate gene expression, followed by Tandem mass tag (TMT)-mass spectrometry and RNA-sequencing. Tumor xenograft models were established for in vivo experiments.
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Nov 28, 2024 |
nature.com | Yang Luo |Xin Wang |Qingyun Liu |Junhao Zhu |Roger Calderon |Sahadevan Raman | +4 more
AbstractInfectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.06, 95%CI: 4.87 − 20.77, P = 7.92 × 10−8) in the FLOT1 gene and a subclavaluee of Mtb Lineage 2.
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Nov 26, 2024 |
nature.com | Wenyuan Xu |Yinghan Chen |Xin Wang
AbstractHydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the bioorthogonal reaction triggered H2S donors are still rare. Here we show one type of bioorthogonal H2S donors, sydnthiones (1,2,3-oxadiazol-3-ium-5-thiolate derivatives), which was designed with the aid of density functional theory (DFT) calculations. The reactions between sydnthiones and strained alkynes provide a platform for controllable, tunable and mitochondria-targeted release of H2S.
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