Ronald Allan Panganiban

Jul 14, 2024 | onlinelibrary.wiley.com | Ronald Allan Panganiban |Kari C. Nadeau |Quan Lu

1 PYROPTOSIS: A NEWLY CHARACTERIZED FORM OF PROGRAMMED CELL DEATH Pyroptosis is a highly inflammatory form of cell death characterized by membrane permeabilization, release of cellular contents such as pro-inflammatory cytokines, and cell lysis.1 The term ‘pyroptosis’ was first coined by Cookson and Brennan in 2001 to denote a form of regulated cell demise in macrophages caused by Salmonella infection that was distinct from either necrotic or apoptotic cell death.2 ‘Pyroptosis’ originated...