Kari C. Nadeau

2 weeks ago | nature.com | Mathias Nielsen |Elena Gissi |Kari C. Nadeau

AbstractIntersectionality describes interdependent systems of inequality related to sex, gender, race, age, class and other socio-political dimensions. By focusing on the compounded effects of social categories, intersectional analysis can enhance the accuracy and experimental efficiency of science.

1 month ago | onlinelibrary.wiley.com | Gennaro D'Amato |Allergic Diseases |Ioana Agache |Kari C. Nadeau

The Los Angeles wildfire is a critical reminder of the respiratory effects of wildfire smoke exposure. Bush, vegetation, forest, and grass fires are widely prevalent around the world, and their incidence and severity are increasing. Their cause may be deliberate or accidental in relation to global warming. Wildfires are strongly associated with the incidence of drought and heat waves, whose occurrence and intensity are accelerated by climate change [1-5].

Jan 22, 2025 | nature.com | Emmanuel Stephen-Victor |Gavin A. Kuziel |Mehdi Benamar |Jason Fong |Kari C. Nadeau |David Breault | +2 more

AbstractTolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis1,2. However, the mechanisms resulting in both the maintenance and failure of tolerance to food antigens are poorly understood. Here we demonstrate that the goblet-cell-derived resistin-like molecule β (RELMβ)3,4 is a critical regulator of oral tolerance. RELMβ is abundant in the sera of both patients with FA and mouse models of FA.

Oct 30, 2024 | onlinelibrary.wiley.com | Mary Johnson |Olivia Kline |Kari C. Nadeau

• , , , , . Anaphylaxis rates associated with COVID-19 vaccines are comparable to those of other vaccines . Vaccine. ; ( ): - . • , , . What have we learned about the allergenicity and adverse reactions associated with the severe acute respiratory syndrome coronavirus 2 vaccines: one year later . Ann Allergy Asthma Immunol. ; ( ): - . • , , , et al. COVID-19 vaccination in patients with reported allergic reactions: updated evidence and suggested approach . J Allergy Clin Immunol Pract. ; ( ): - .

Jul 14, 2024 | onlinelibrary.wiley.com | Ronald Allan Panganiban |Kari C. Nadeau |Quan Lu

1 PYROPTOSIS: A NEWLY CHARACTERIZED FORM OF PROGRAMMED CELL DEATH Pyroptosis is a highly inflammatory form of cell death characterized by membrane permeabilization, release of cellular contents such as pro-inflammatory cytokines, and cell lysis.1 The term ‘pyroptosis’ was first coined by Cookson and Brennan in 2001 to denote a form of regulated cell demise in macrophages caused by Salmonella infection that was distinct from either necrotic or apoptotic cell death.2 ‘Pyroptosis’ originated...