Ronny Drapkin

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Articles

Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency - Nature Communications

Jun 2, 2024 | nature.com | Judit Jimenez-Sainz |Dipika Gupta |Ronny Drapkin |Ryan Jensen |Duncan Smith |Eli Rothenberg

AbstractBRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we provide evidence that BRCA2 acts as a critical suppressor of head-on transcription-replication conflicts (HO-TRCs).
Progress in Ovarian Cancer: Discovery of Fallopian Tube Involvement

Jun 26, 2023 | mdedge.com | Ronny Drapkin

The field of ovarian cancer has experienced a paradigm shift; ovarian cancer is now known to most often arise from the fallopian tubes.1 The ovaries can act as a magnet for tumor cells that may originate elsewhere in the body.

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