Ryan Jensen

Featured in: Favicon

nature.com Favicon

appeal-democrat.com Favicon

recorderonline.com Favicon

Articles

Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency - Nature Communications

Jun 2, 2024 | nature.com | Judit Jimenez-Sainz |Dipika Gupta |Ronny Drapkin |Ryan Jensen |Duncan Smith |Eli Rothenberg

AbstractBRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we provide evidence that BRCA2 acts as a critical suppressor of head-on transcription-replication conflicts (HO-TRCs).

Contact details

Emails

[email protected]

Socials & Sites

Try JournoFinder For Free

Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.

Start Your 7-Day Free Trial →