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Jan 24, 2025 | 
hoover.org | Ross Levine
MyHoover delivers a personalized experience at Hoover.org. In a few easy steps, create an account and receive the most recent analysis from Hoover fellows tailored to your specific policy interests. Watch this video for an overview of MyHoover. Create Account
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Jan 24, 2025 | 
msn.com | Ross Levine
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Oct 4, 2024 | 
nature.com | Maarten WJ Fornerod |Deedra Nicolet |Benjamin Kelly |Krzysztof Mrózek |Jean F. Kloppers |Anne-Cecilia van Marle | +21 more
AbstractGenomic profiles and prognostic biomarkers in patients with acute myeloid leukemia (AML) from ancestry-diverse populations are underexplored. We analyzed the exomes and transcriptomes of 100 patients with AML with genomically confirmed African ancestry (Black; Alliance) and compared their somatic mutation frequencies with those of 323 self-reported white patients with AML, 55% of whom had genomically confirmed European ancestry (white; BeatAML).
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Jul 24, 2024 | 
nature.com | Ross Levine
The mainly hematologic expression profile of phosphatidylinositol-3-kinase-γ (PI3Kγ) makes it an attractive therapeutic target. Recent work from three independent groups shows that inhibiting PI3Kγ impairs the metabolism and growth of acute myeloid leukemia cells — a finding that justifies further mechanistic and clinical exploration.
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May 8, 2024 | 
nature.com | Franco Izzo |Robert Myers |Levan Mekerishvili |Elliot Eton |Eleni P. Mimitou |Daniel Choi | +6 more
AbstractIn somatic tissue differentiation, chromatin accessibility changes govern priming and precursor commitment towards cellular fates1,2,3. Therefore, somatic mutations are likely to alter chromatin accessibility patterns, as they disrupt differentiation topologies leading to abnormal clonal outgrowth. However, defining the impact of somatic mutations on the epigenome in human samples is challenging due to admixed mutated and wild-type cells.
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Nov 27, 2023 | 
nature.com | Ross Levine
NEWS AND VIEWS 27 November 2023 In 2008, the first comprehensive sequence of a cancer genome was reported, ushering in a new era of molecular diagnostic, prognostic and therapeutic advances informed by an essential framework to understand cancer’s complexities.
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Nov 20, 2023 | 
nature.com | Ross Levine
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02406-4, 4 July 2023. In the version of the article initially published, the Acknowledgements section did not mention that the article was also supported by a grant from the Edward P. Evans Foundation. This has been added in the HTML and PDF versions of the article. About this articleSánchez Vela, P., Trowbridge, J.J. & Levine, R.L. Author Correction: Clonal hematopoiesis, aging and Alzheimer’s disease. Nat Med (2023).
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Jul 10, 2023 | 
nature.com | Michael Deininger |Ross Levine
AbstractDespite significant advances in developing selective JAK2 inhibitors, JAK2 kinase inhibitor (TKI) therapy is ineffective in suppressing the disease. Reactivation of compensatory MEK-ERK and PI3K survival pathways sustained by inflammatory cytokine signaling causes treatment failure. Concomitant inhibition of MAPK pathway and JAK2 signaling showed improved in vivo efficacy compared to JAK2 inhibition alone but lacked clonal selectivity.
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Jul 4, 2023 | 
nature.com | Ross Levine
Unexpectedly, new data show that clonal hematopoiesis is associated with protection from Alzheimer’s disease; it is imperative that future studies unravel the complex tissue–disease contexts in which clonal hematopoiesis arises and contributes to aging-associated diseases. Bouzid et al. analyzed data from two large, independent patient cohorts, the Framingham Heart Study and the Cardiovascular Health Study, to show that CH is associated with a decreased incidence of AD9.
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Mar 23, 2023 | 
sfchronicle.com | Ross Levine
Ross LevineMarch 23, 2023 By most accounts, the country seems to have averted any doomsday scenarios stemming from the collapse of Silicon Valley Bank. On Wednesday, the Federal Reserve unexpectedly hiked interest rates once more, suggesting that it views the banking system as sufficiently calm that it can continue its battle against inflation. But don’t be so sure about the banking system’s stability.
