Roy Parker

2 weeks ago | genesdev.cshlp.org | Meaghan Van Alstyne |James Pratt |Roy Parker

1,2,3 1Department of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80301, USA; 2Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado 80301, USA; 3BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado 80301, USA Corresponding author: roy.parker{at}colorado.edu Footnotes Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.352551.124.

Aug 4, 2023 | jbc.org | Roy Parker

ABSTRACTThe levels of non-coding RNAs (ncRNAs) are regulated by transcription, RNA processing, and RNA degradation pathways. One mechanism for the degradation of ncRNAs involves the addition of oligo(A) tails by noncanonical poly(A) polymerases, which then recruit processive sequence-independent 3’ to 5’ exonucleases for RNA degradation.