Roy V. Sillitoe

Jul 10, 2024 | nature.com | Ila Mishra |Bing Feng |Linda Kim |Tao Lin |Aaron Sathyanesan |Roy V. Sillitoe | +2 more

AbstractThe cerebellum, a phylogenetically ancient brain region, has long been considered strictly a motor control structure. Recent studies have implicated the cerebellum in cognition, sensation, emotion and autonomic function, making it an important target for further investigation.

May 21, 2024 | biorxiv.org | Megan Nguyen |Amanda Brown |Tao Lin |Roy V. Sillitoe

AbstractDystonia is the third most common movement disorder and an incapacitating co-morbidity in a variety of neurologic conditions. Dystonia can be caused by genetic, degenerative, idiopathic, and acquired etiologies, which are hypothesized to converge on a dystonia network consisting of the basal ganglia, thalamus, cerebellum, and cerebral cortex.

Apr 25, 2024 | biorxiv.org | Amanda Brown |Dominic J. Kizek |Roy V. Sillitoe

AbstractThe cerebellum contributes to a diverse array of motor conditions including ataxia, dystonia, and tremor. The neural substrates that encode this diversity are unclear. Here, we tested whether the neural spike activity of cerebellar output neurons is distinct between movement disorders with different impairments, generalizable across movement disorders with similar impairments, and capable of causing distinct movement impairments.

Nov 2, 2023 | biorxiv.org | Linda Kim |Roy V. Sillitoe

AbstractDystonia arises with cerebellar dysfunction, which plays a key role in the emergence of multiple pathophysiological deficits that range from abnormal movements and postures to disrupted sleep. Current therapeutic interventions typically do not simultaneously address both the motor and non-motor (sleep-related) symptoms of dystonia, underscoring the necessity for a multi-functional therapeutic strategy.

Aug 19, 2023 | biorxiv.org | Amanda Brown |Dominic J. Kizek |Roy V. Sillitoe

AbstractThe cerebellum contributes to a diverse array of motor conditions including ataxia, dystonia, and tremor. The neural substrates that encode this diversity are unclear. Here, we tested whether the neural spike activity of cerebellar output neurons predicts the phenotypic presentation of cerebellar pathophysiology. Using in vivo awake recordings as input data, we trained a supervised classifier model to differentiate the spike parameters between mouse models for ataxia, dystonia, and tremor.