Ruben Smith

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Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease - Nature Communications

Sep 14, 2024 | nature.com | Lyduine E. Collij |Ruben Smith |Sebastian Palmqvist |Rik Ossenkoppele

AbstractIdentifying concomitant Lewy body (LB) pathology through seed amplification assays (SAA) might enhance the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice and trials. This study examined whether LB pathology exacerbates AD-related disease progression in 795 cognitively impaired individuals (Mild Cognitive Impairment and dementia) from the longitudinal multi-center observational ADNI cohort.

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