Lyduine E. Collij

Sep 14, 2024 | nature.com | Lyduine E. Collij |Ruben Smith |Sebastian Palmqvist |Rik Ossenkoppele

AbstractIdentifying concomitant Lewy body (LB) pathology through seed amplification assays (SAA) might enhance the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice and trials. This study examined whether LB pathology exacerbates AD-related disease progression in 795 cognitively impaired individuals (Mild Cognitive Impairment and dementia) from the longitudinal multi-center observational ADNI cohort.

Jun 14, 2024 | nature.com | Sophie E Mastenbroek |Jacob Vogel |Lyduine E. Collij |Alexandra Young |Frederik Barkhof |Rik Ossenkoppele

AbstractLewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology.

May 20, 2024 | journals.plos.org | Vrije Universiteit Amsterdam |Amsterdam Neuroscience |Amsterdam UMC |Lyduine E. Collij

Citation: Rhodius-Meester HFM, van Maurik IS, Collij LE, van Gils AM, Koikkalainen J, Tolonen A, et al. (2024) Computerized decision support is an effective approach to select memory clinic patients for amyloid-PET. PLoS ONE 19(5): e0303111. https://doi.org/10.1371/journal.pone.0303111Editor: Wataru Araki, National Center of Neurology and Psychiatry (NCNP), JAPANReceived: October 26, 2023; Accepted: April 18, 2024; Published: May 20, 2024Copyright: © 2024 Rhodius-Meester et al.