Ruiqing Zheng

Dec 3, 2024 | biorxiv.org | Xuhua Yan |Jinmiao Chen |Ruiqing Zheng

AbstractThe integration of single-cell multi-omics datasets is critical for deciphering cellular heterogeneities. Mosaic integration, the most general integration task, poses a greater challenge regarding disparity in modality abundance across datasets. Here, we present ACE, a mosaic integration framework that assembles two types of strategies to handle this problem: modality-alignment based strategy (ACE-align) and regression-based strategy (ACE-spec).