Rumiana Dimova

Aug 19, 2024 | biorxiv.org | Mareike S. Stephan |Nina K. Broeker |Tom Robinson |Rumiana Dimova

AbstractGiant unilamellar vesicles (GUVs) are a versatile platform to study cell membrane functions. We have constructed phospholipid GUVs presenting lipopolysaccharide on their external surface (LPS-GUVs) to mimic the outer membrane (OM) of Gram-negative bacteria. GUVs allow for adjusting a defined OM composition, unlike the dynamic changes of LPS structures typically observed in vivo. The OM is a major control point for the viral genome transfer from bacteriophages into bacterial hosts.

Apr 8, 2024 | pure.mpg.de | Rumiana Dimova

Volltexte (frei zugänglich) Ergänzendes Material (frei zugänglich) Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar Mangiarotti, A., & Dimova, R. Biomolecular condensates in contact with membranes. Annual Review of Biophysics, 53, 319-341. doi:10.1146/annurev-biophys-030722-121518.

Dec 27, 2023 | nature.com | Rumiana Dimova

Liquid–liquid phase separation (LLPS) within cells is a captivating phenomenon known to aid the organization of cellular components; however, its complex kinetics have remained a puzzle. Now, a new study elucidates the crosstalk between the phase state of an encapsulating membrane and LLPS dynamics. When binary fluids undergo phase separation, they transition from a uniform, homogeneous phase to a far-from-equilibrium state.