Ruta Chitale

2 months ago | nature.com | Sharmishtha Musalgaonkar |James Yelland |Ruta Chitale |David Taylor |Can Cenik

AbstractAssembly of functional ribosomal subunits and successfully delivering them to the translating pool is a prerequisite for protein synthesis and cell growth. In S. cerevisiae, the ribosome assembly factor Reh1 binds to pre-60S subunits at a late stage during their cytoplasmic maturation. Previous work shows that the C-terminus of Reh1 inserts into the polypeptide exit tunnel of the pre-60S subunit.

Oct 23, 2023 | biorxiv.org | Sharmishtha Musalgaonkar |James Yelland |Shilpa Rao |Ruta Chitale

AbstractAssembly of functional ribosomal subunits and successfully delivering them to the translating pool is a prerequisite for protein synthesis and cell growth. In S. cerevisiae, the ribosome assembly factor Reh1 binds to pre-60S subunits at a late stage during their cytoplasmic maturation. Previous work shows that the C-terminus of Reh1 inserts into the polypeptide exit tunnel (PET) of the pre-60S subunit.