David Taylor

2 months ago | nature.com | Sharmishtha Musalgaonkar |James Yelland |Ruta Chitale |David Taylor |Can Cenik

AbstractAssembly of functional ribosomal subunits and successfully delivering them to the translating pool is a prerequisite for protein synthesis and cell growth. In S. cerevisiae, the ribosome assembly factor Reh1 binds to pre-60S subunits at a late stage during their cytoplasmic maturation. Previous work shows that the C-terminus of Reh1 inserts into the polypeptide exit tunnel of the pre-60S subunit.

Nov 19, 2024 | biorxiv.org | Grace Hibshman |David Taylor

AbstractThe Cas9 endonuclease from Streptococcus pyogenes (SpCas9) has revolutionized genome editing, as it can be programmed by an RNA sequence to target and cleave DNA. However, SpCas9 is prone to deleterious off-target effects, prompting efforts to develop and discover high-fidelity variants. In the search for a more precise genome editor, many intrinsically specific Cas9 orthologs have been found in nature.

Oct 2, 2024 | cambridge.org | Emilio Fernandez-Egea |Robert J. Flanagan |David Taylor |Fiona Gaughran

It is undeniable that clozapine can lead to fatal outcomes if its toxic effects are not promptly identified and managed. While acknowledging the risks associated with clozapine, media reports can overestimate the number of fatal outcomes due to the drug.

Sep 19, 2023 | pharmaceutical-journal.com | Mark Horowitz |David Taylor

After reading this article, you should be able to:Understand the rationale for tapering antidepressants gradually, in a hyperbolic pattern and a rate titrated to the individual;Counsel a patient on how to undertake a careful, hyperbolic ;Help a patient use different formulations of medication to facilitate this process. It is now recognised that withdrawal effects from antidepressants are more common, and can be more severe and long-lasting than previously understood.

Jun 7, 2023 | jamanetwork.com | Ebenezer Oloyede |David Taylor |South London

International Variation in Clozapine Hematologic Monitoring—A Call for Action Clozapine was first synthesized in the 1950s but remains the only licensed medication for treatment-resistant psychosis.1 Treatment-resistant psychosis, defined as the persistence of psychotic symptoms despite sequential antipsychotic treatment, is a major cause of disability and functional impairment worldwide.1 Within the past decade, there has been a commitment among health institutions to address clozapine...