Ryan J. Malonis

Sep 18, 2023 | onlinelibrary.wiley.com | Adam G Kreutzer |Ryan J. Malonis |Karen Tong |Gretchen Guaglianone

1 INTRODUCTION Understanding the structures of the toxic oligomers formed by the β-amyloid peptide (Aβ) is crucial for unraveling the molecular basis of Alzheimer's disease and for creating better Alzheimer's disease therapies.[1, 2] Elucidating the structures of Aβ oligomers that form in the brain is challenging, because the oligomers are unstable and heterogeneous, constituting a multitude of assemblies that differ in size, stoichiometry, and morphology.[3] Furthermore, isolation of Aβ...