Gretchen Guaglianone

Dec 8, 2023 | pubs.rsc.org | Tuan D. Samdin |Chelsea Jones |Gretchen Guaglianone |Adam G Kreutzer

A β-barrel-like tetramer formed by a β-hairpin derived from Aβ† β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three different alignments of β-hairpins have been observed in the structures of Aβ oligomers or fibrils. Differences in β-hairpin alignment likely contribute to the heterogeneity of Aβ oligomers and thus impede their study at high-resolution.

Nov 28, 2023 | pubs.rsc.org | Chelsea Jones |Gretchen Guaglianone |Adam G Kreutzer |Tuan Dilshad Samdin

A β-Barrel-Like Tetramer Formed by a β-Hairpin Derived From Aβ β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three different alignments of β-hairpins have been observed in the structures of Aβ oligomers or fibrils. Differences in β-hairpin alignment likely contribute to the heterogeneity of Aβ oligomers and thus impede their study at high-resolution.

Sep 18, 2023 | onlinelibrary.wiley.com | Adam G Kreutzer |Ryan J. Malonis |Karen Tong |Gretchen Guaglianone

1 INTRODUCTION Understanding the structures of the toxic oligomers formed by the β-amyloid peptide (Aβ) is crucial for unraveling the molecular basis of Alzheimer's disease and for creating better Alzheimer's disease therapies.[1, 2] Elucidating the structures of Aβ oligomers that form in the brain is challenging, because the oligomers are unstable and heterogeneous, constituting a multitude of assemblies that differ in size, stoichiometry, and morphology.[3] Furthermore, isolation of Aβ...

May 12, 2023 | biorxiv.org | Adam G Kreutzer |Sepehr Haerianardakani |Gretchen Guaglianone |Jennifer Nguyen

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