Ryan Lumpkin

Mar 20, 2024 | nature.com | Hai-Tsang Huang |Ryan Lumpkin |Yuan Xiong |James Chen |Katherine A. Donovan |Eric S. Fischer | +2 more

AbstractProtein ubiquitylation controls diverse processes within eukaryotic cells, including protein degradation, and is often dysregulated in disease. Moreover, small-molecule degraders that redirect ubiquitylation activities toward disease targets are an emerging and promising therapeutic class. Over 600 E3 ubiquitin ligases are expressed in humans, but their substrates remain largely elusive, necessitating the development of new methods for their discovery.