Saeede Salehi

Aug 27, 2024 | nature.com | Abdolhossein Zare |Saeede Salehi |Jakob M. Bader |Utz Fischer |Alexander Veh |Panagiota Arampatzi | +2 more

AbstractMotoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about the mechanisms regulating axonal protein synthesis.

Jul 12, 2023 | nature.com | Jakob M. Bader |Utz Fischer |Felix Meissner |Matthias Mann |Michael Briese |Saeede Salehi | +1 more

AbstractThe neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and branching. While its functions in alternative splicing have been described in detail, cytosolic roles of Ptbp2 for axon growth have remained elusive.