Sandhya Sharma

2 months ago | nature.com | Che-Hsing Li |Sandhya Sharma |Andras Heczey |Mae Woods |Sachin G. Thakkar |Mengfen Wu | +7 more

In a phase 1 clinical trial open to accrual from 2004 to 2009, we treated children with neuroblastoma with Epstein–Barr virus (EBV)-specific T lymphocytes and CD3-activated T cells—each expressing chimeric antigen receptors (CARs) targeting GD2 but without an embedded co-stimulatory sequence (first-generation CARs). These CARs incorporated barcoded sequences to track each infused population. We previously reported outcomes up to 5 years and now report long-term outcomes up to 18 years. Of 11 patients with active disease at infusion, three achieved a complete response that was sustained in two patients, one for 8 years until lost to follow-up and one for more than 18 years. Of eight patients with no evidence of disease at the time of CAR-T administration, five are disease free at their last follow-up between 10 years and 15 years after infusion. Intermittent low levels of transgene were detected during the follow-up period with significantly greater persistence in those who were long-term survivors. Despite using first-generation vectors that are no longer employed because of the lack of co-stimulatory domains, patients with relapsed/refractory neuroblastoma achieved long-term disease control after receiving GD2 CAR-T cell therapy, including one patient now in remission of relapsed disease for more than 18 years. ClinicalTrials.gov identifier: NCT00085930 . In an extended follow-up of a phase 1 trial evaluating a first-generation GD2-directed CAR-T cell therapy in patients with neuroblastoma, one patient has had a sustained clinical response for over 18 years without requiring any additional therapy, with translational data from long-term survivors providing broader insights into potential determinants of CAR-T cell response.

Nov 7, 2024 | eurasiantimes.com | Sandhya Sharma

By Sandhya SharmaIn what could be seen as the biggest vindication of India’s long-standing stance that Canada is struggling to deal with transnational crime groups from Punjab, the RCMP (Royal Canadian Mounted Police) has busted a drug “superlab” in Falkland, B.C., worth nearly US$490 million, run by a Punjab-origin mastermind, allegedly having Khalistani connections.

Oct 14, 2024 | eurasiantimes.com | Sandhya Sharma

By: Sandhya SharmaAs Britain decided to relinquish its sovereignty over the Chagos Islands and transfer control to Mauritius, one might question whether the former ‘Great’ Britain should also grant Argentina “full sovereignty” over the Falkland Islands. In a strategic and historically unprecedented decision, Britain transferred its imperial control over sixty islands in the Chagos Archipelago to Mauritius while keeping the strategically important UK-US military base at Diego Garcia.

Jul 25, 2024 | mdpi.com | Sandhya Sharma |Massimo Caputi |Waseem Asghar

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Jan 9, 2024 | sooperarticles.com | Sandhya Sharma

Mental health refers to a person's emotional, psychological, and social well-being. It involves the individual's ability to handle stress, relate to others, make decisions, and cope with the challenges of life. Mental health is a crucial aspect of overall health and affects how people think, feel, and behave.