Sandra Aleksic

Oct 13, 2024 | biorxiv.org | Amanat Ali |Zhengdong Zhang |Tina Gao |Sandra Aleksic

AbstractDiminished signaling via insulin/insulin-like growth factor-1 (IGF-1) axis is associated with longevity in different model organisms. IGF-1 gene is highly conserved across species, with only few evolutionary changes identified in it. Despite its potential role in regulating lifespan, no coding variants in IGF-1 have been reported in human longevity cohorts to date.