Sandra Sanchez-Roige

2 months ago | nature.com | Diego L. Rovaris |Sintia I. Belangero |Sheila T. Nagamatsu |Caroline M Nievergelt |Roseann E. Peterson |Laura Sloofman | +28 more

AbstractPsychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations.

Nov 8, 2023 | jamanetwork.com | Peter Barr |Tim B. Bigdeli |Sandra Sanchez-Roige

Key PointsQuestion  What are the correlates of risk for disinhibited behaviors in the US veterans population? Findings  In this cohort study including electronic health record data of 560 824 veterans, risk for disinhibited behaviors was associated with medical outcomes across all bodily systems, including substance use disorders, suicide and self-harm, liver disease, chronic airway obstruction, and viral hepatitis C.