Caroline M Nievergelt

2 months ago | nature.com | Diego L. Rovaris |Sintia I. Belangero |Sheila T. Nagamatsu |Caroline M Nievergelt |Roseann E. Peterson |Laura Sloofman | +28 more

AbstractPsychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations.

Jan 24, 2025 | digitalcommons.library.tmc.edu | Jonas Bybjerg-Grauholm |Peter Roy-Byrne |Caroline M Nievergelt |Adam X. Maihofer

KeywordsHumans, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Neurobiology, Polymorphism, Single Nucleotide, Stress Disorders, Post-Traumatic, White People, White, Black or African American, American Indian or Alaska NativeAbstractPost-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited.

Apr 25, 2024 | universityofcalifornia.edu | Caroline M Nievergelt |Joseph McClain

The group recently announced their findings from a genome-wide association study of 1,222,822 people in a paper recently published in the journal Nature Genetics. Caroline M. Nievergelt, Ph.D., professor of psychiatry at UC San Diego School of Medicine, is the co-first author on the paper, together with Adam X. Maihofer, PhD., an assistant project scientist in Nievergelt’s lab. PGC-PTSD co-chair Murray B.