Sanjay Manohar

Dec 8, 2024 | biorxiv.org | Lin Sun |Sanjay Manohar

AbstractSyntax is a central organizing component of human language but few models explain how it may be implemented in neurons. We combined two rapid synaptic rules to demonstrate how neurons can implement a simple grammar without accounting for the hierarchical property of syntax. Words bind to syntactic roles (e.g. 'dog' as subject or object) and the roles obey ordering rules (e.g. subject → verb → object), guided by predefined syntactic knowledge.

Jul 21, 2024 | medrxiv.org | Kengo Shibata |Cheng Chen |Xin You Tai |Sanjay Manohar

The authors have declared no competing interest. This work was funded by Wellcome Trust Principal Research Fellowship to MH, the MRC Clinician Scientist Fellowship [MR/P00878X] and NIH Oxford Biomedical Research Centre to SGM, the Wellcome Trust PhD clinical fellowship to XT and the Berrow Foundation Scholarship to KS. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Jul 10, 2024 | jneurosci.org | Adam AJ Al-Diwani |John Grogan |Sanjay Manohar

N-Methyl-D-Aspartate Receptor-Antibody Encephalitis Impairs Maintenance of Attention to Items in Working Memory Afrose Dor, Corin Harrison, Sarosh R. Irani, Adam Al-Diwani, John Grogan, Sanjay Manohar Journal of Neuroscience 10 July 2024, 44 (28) e1500232024; DOI: 10.1523/JNEUROSCI.1500-23.2024

May 29, 2024 | jneurosci.org | Adam AJ Al-Diwani |John Grogan |Sanjay Manohar

AbstractNMDA receptors (NMDAR) may be crucial to working memory (WM). Computational models predict that they sustain neural firing and produce associative memory, which may underpin maintaining and binding information respectively. We test this in patients with antibodies to NMDAR (n=10, female) and compare them with healthy control participants (n=55, 20 male, 35 female). Patients were tested after recovery with a task that separates two aspects of WM: sustaining attention and feature binding.

May 15, 2024 | biorxiv.org | Xin You Tai |Masud Husain |Sanjay Manohar

AbstractPattern separation and pattern completion are distinct neurocognitive processes involved in encoding and retrieval of memories. However, there is currently no robust behavioural task in humans to measure both processes within the same paradigm. We describe the Memory Pinhole task, a novel paradigm which offers a distinct measure of each process, applied to healthy young, healthy older and people with epilepsy.