Masud Husain

1 month ago | academic.oup.com | Masud Husain |Camille Bégin |Stefano Sandrone |Carlo Reverberi

Mar 11, 2025 | bmj.com | Masud Husain

Masud Husain, professorNuffield Department of Clinical Neurosciences, University of Oxford, UKTo revive clinical research in the UK we need to streamline systems and dismantle bureaucracy, writes Masud HusainClinical research in the UK is now at a critical point. What used to be a shining example across the world has become slow, ponderous, and inefficient.

Mar 6, 2025 | academic.oup.com | Masud Husain |Alain Goriely |Gavin Giovannoni |Ian Harrison

Heart failure can lead to reduced cerebral blood flow, neurodegeneration and cognitive decline. In a mouse model of heart failure, Kritsilis et al. show that cerebral blood flow helps regulate the brain’s glymphatic system, and that heart failure can disrupt glymphatic system homeostasis. See Harrison (https://doi.org/10.1093/brain/awaf054) for a scientific commentary on this article.

Oct 16, 2024 | alz-journals.onlinelibrary.wiley.com | Bahaaeddin Attaallah |Sofia Toniolo |Maria Raquel Maio |Masud Husain

1 INTRODUCTION Apathy (ie, diminished goal-directed behavior) is a prominent feature in several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and small vessel disease (SVD).1 It burdens patients and caregivers and is a marker of disease progression in some disorders.2, 3 In AD, up to 80% of patients develop apathy, even at early stages, making it a valuable preclinical marker.4 However, it remains poorly understood in AD, with limited behavioral...

May 15, 2024 | biorxiv.org | Xin You Tai |Masud Husain |Sanjay Manohar

AbstractPattern separation and pattern completion are distinct neurocognitive processes involved in encoding and retrieval of memories. However, there is currently no robust behavioural task in humans to measure both processes within the same paradigm. We describe the Memory Pinhole task, a novel paradigm which offers a distinct measure of each process, applied to healthy young, healthy older and people with epilepsy.