Sanna Madan

1 month ago | biorxiv.org | Sanna Madan |Tiangen Chang |Alexandra Harris |Huaitian Liu

AbstractChimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies. However, its application in solid tumors remains limited because single targets are unlikely to suffice due to tumor antigen heterogeneity and off-tumor toxicities.

Nov 15, 2024 | biorxiv.org | Di Wu |Sanna Madan |Sanju Sinha |Yael Gurevich Schmidt

AbstractThe aging of the immune system substantially impacts individual immune responses, yet accurately quantifying immune age remains a complex challenge. Here we developed IMMClock, a novel immune aging clock that uses gene expression data to predict the biological age of individual CD8⁺ T cells, CD4⁺ T cells, and NK cells. The accuracy of IMMClock is first validated across multiple independent datasets, demonstrating its robustness.