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2 months ago | 
febs.onlinelibrary.wiley.com | Di Wu |Yan Zhao |Daohua Jiang
Conflicts of interest The authors declare no conflict of interest. References 1, & (1995) Vesicular neurotransmitter transporters: from bacteria to humans. Physiol Rev 75, 369–392. 2, , & (2015) Monoamine neurotransmitter disorders: clinical advances and future perspectives. Nat Rev Neurol 11, 567–584. 3, & (1981) Proton: substrate stoichiometries during active transport of biogenic amines in chromaffin ghosts. J Biol Chem 256, 5773–5780.
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Jan 20, 2025 | 
pubs.acs.org | Shuyu Li |Di Wu |Hui Yu |Xin Huang
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Jan 20, 2025 | 
dx.doi.org | Shuyu Li |Di Wu |Hui Yu |Xin Huang
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Jan 13, 2025 | 
respiratory-research.biomedcentral.com | Di Wu |Jing Gao |Kun Wang |Wujian Xu |Feilong Wang |Zhixian Jin | +4 more
Instead of expensive and giant cryoablation equipment used in clinic, the instruments required for VSCD are commonly available in general laboratories, mainly including liquid nitrogen tank, liquid nitrogen pen, stereomicroscope, microforceps, 75% alcohol, operating board, ophthalmic curved scissors, hemostat, forceps, and timer (Fig. 1A).
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Jan 13, 2025 | 
nature.com | Kunpeng Ma |Yanli Dong |Jun Zhao |Di Wu |Daohua Jiang
AbstractThe vesicular acetylcholine transporter (VAChT) has a pivotal role in packaging and transporting acetylcholine for exocytotic release, serving as a vital component of cholinergic neurotransmission. Dysregulation of its function can result in neurological disorders. It also serves as a target for developing radiotracers to quantify cholinergic neuron deficits in neurodegenerative conditions.
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Jan 13, 2025 | 
nature.com | Corinne A. Lutomski |Tarick J. El-Baba |Di Wu |Weston Struwe
AbstractUnderstanding the dynamics of membrane protein–ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to the effects of protein modifications. In this study, using the archetypal G protein-coupled receptor rhodopsin, we found that the receptor and its effectors can be released directly from retina rod disc membranes using infrared irradiation in a mass spectrometer.
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Jan 10, 2025 | 00544-6&sz=64)
cell.com | Zhenlin Ouyang |Wenbo He |Di Wu |Lei Duan |Min Jiao |Xiaoyu He | +9 more
Keywordsefflux pumpAcinetobacter baumanniimultidrug resistanceAdeGcryoelectron microscopyGet full text accessLog in, subscribe or purchase for full access. References1. De Oliveira, D.M.P. ∙ Forde, B.M. ∙ Kidd, T.J. ... Antimicrobial Resistance in ESKAPE PathogensClin. Microbiol. Rev. 2020; 33, e00181-192. Sarshar, M. ∙ Behzadi, P. ∙ Scribano, D. ... Acinetobacter baumannii: An Ancient Commensal with Weapons of a PathogenPathogens. 2021; 10, 3873. Tacconelli, E. ∙ Carrara, E. ∙ Savoldi, A. ...
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Jan 3, 2025 | 
mdpi.com | Di Wu
1. IntroductionThe tensile, compressive, and shear properties of steel box girder bridges prove to be significantly superior when compared to other types of bridges [1,2,3,4]. However, due to various factors such as structural characteristics, stress characteristics, and processing technologies, numerous challenging problems remain unsolved [5,6,7].
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Dec 27, 2024 | 
mdpi.com | Di Wu
2. Methods and Data 2.1. Study AreaThe forest in this study is over 500 km2 in size, with dimensions of roughly 21.66 km east to west and 24.14 km north to south. It is in Shangzhi City, Heilongjiang Province, China (127°20′ to 127°50′E, 45°05′ to 45°30′N) (). With a frost-free period of approximately 125 days and an average temperature of 2.4 °C, the area displays traits of a subarctic monsoon climate. Rainfall is mostly concentrated from May to September, with an average of 700 mm per year.
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Dec 22, 2024 | 
mdpi.com | Di Wu
1. IntroductionCalcium (Ca2+) is an essential element in plants, acting as a second messenger in response to extracellular signals. The Ca2+/cation antiporter (CaCA) superfamily is critical in regulating and accumulating calcium [1,2,3]. This superfamily encompasses distinct clades with varied phylogenetic, structural, and functional characteristics [4].
