Sanofi Paris France

1 month ago | dom-pubs.onlinelibrary.wiley.com | Steve Edelman |Daniel Agardh |Nancy Yufei Cui |Sanofi Paris France

1 INTRODUCTION Type 1 diabetes (T1D) is the result of a deficiency of insulin secretion caused by the autoimmune-mediated destruction of pancreatic islet beta cells.1, 2 The pathogenesis of T1D includes autoreactive immunological mechanisms involving various immune cells and mediators.3 T1D is characterised by the presence of autoantibodies to multiple islet autoantigens, which are well-established markers of islet autoimmunity.4, 5 The positive effect of immunomodulation on beta-cell...