Sara Flamini

Nov 20, 2024 | nature.com | Marco Rosichini |Giada Del Baldo |Francesca Benini |Shirley Genah |Maria Vinci |Sara Flamini | +9 more

Optimal immune function is crucial in preventing cancer development and growth and for the success of anti-cancer therapies. Here, we characterized the peripheral immunological status of 83 steroids-naïve pediatric patients with central nervous system neoplasia at the disease onset. Tumors were classified into low-grade gliomas (LGG), high-grade gliomas (HGG), medulloblastoma, and other tumors. We revealed that glioma patients showed an altered lymphocyte pool. T-cells of HGG patients shifted from naïve to effector memory phenotype. LGG patients exhibited T-cell central memory expansion and higher T-cell activation. Interestingly, HGG patients displayed reduced thymic function. Furthermore, LGG and HGG patients showed reduced activated B-cells and suboptimal B-cell formation. Our data demonstrate that glioma patients have reduced lymphopoiesis at the disease onset, which could contribute to the systemic lymphopenia characterizing these patients. This study offers novel insights into the immunological status of brain tumor patients which may help in designing more effective treatments.

May 10, 2024 | mdpi.com | Filippo Lococo |Galal Ghaly |Marco Chiappetta |Sara Flamini

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Sep 16, 2023 | mdpi.com | Sara Flamini |Musetta Paglialunga |Raffaele Contini |Marta Febo

1. IntroductionCurrent anti-inflammatory pharmacological therapies include small molecules and biotechnological drugs; however, inflammatory diseases, including inflammatory bowel diseases (IBDs), remain incurable. Thus, novel therapies for such recurrent and life-threatening conditions are urgently needed. Glucocorticoids (GCs) are endogenous hormones produced and released by the adrenal cortex.

Feb 7, 2023 | jacionline.org | Marco Rosichini |Veronica Bordoni |Domenico Alessandro Silvestris |INMI L Spallanzani |Antonella Cardinale |Giovanna Zambruno | +6 more